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Tatsuyoshi Kono Selected Research

Cytokines

12/2023Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry.
11/2018Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell.
1/2017MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells.
2/2012PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress.

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Tatsuyoshi Kono Research Topics

Disease

6Type 2 Diabetes Mellitus (MODY)
12/2023 - 11/2012
3Obesity
01/2022 - 11/2012
3Hyperglycemia
02/2015 - 02/2012
2Insulin Resistance
10/2016 - 12/2013
1Glucose Intolerance
11/2023
1Weight Gain
01/2020
1Insulinoma
11/2018
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2017
1B-Cell Lymphoma (Lymphoma, B Cell)
01/2017
1Hypertension (High Blood Pressure)
02/2015
1Body Weight (Weight, Body)
10/2013
1Atherosclerosis
11/2012
1Hyperlipidemias (Hyperlipidemia)
11/2012

Drug/Important Bio-Agent (IBA)

5Glucose (Dextrose)FDA LinkGeneric
12/2023 - 02/2015
4CytokinesIBA
12/2023 - 02/2012
3Streptozocin (Streptozotocin)FDA Link
11/2018 - 10/2013
2Proteins (Proteins, Gene)FDA Link
11/2018 - 01/2017
2Insulin (Novolin)FDA Link
12/2013 - 02/2012
1ProinsulinIBA
11/2023
1Glucagon-Like Peptide 1 (GLP 1)IBA
01/2022
1SmokeIBA
01/2020
1PalmitatesIBA
11/2018
1Messenger RNA (mRNA)IBA
11/2018
1Caspase 3 (Caspase-3)IBA
01/2017
1MicroRNAs (MicroRNA)IBA
01/2017
1CholesterolIBA
11/2012
1Thyroid Hormone Receptors (Thyroid Hormone Receptor)IBA
11/2012
1Pioglitazone (Actos)FDA Link
02/2012

Therapy/Procedure

1Injections
10/2013